Cargando…

The rate of spontaneous mutations in yeast deficient for MutSβ function

Mutations in simple sequence repeat loci underlie many inherited disorders in humans, and are increasingly recognized as important determinants of natural phenotypic variation. In eukaryotes, mutations in these sequences are primarily repaired by the MutSβ mismatch repair complex. To better understa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Plavskin, Yevgeniy, de Biase, Maria Stella, Schwarz, Roland F, Siegal, Mark L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997558/ https://www.ncbi.nlm.nih.gov/pubmed/36529906 http://dx.doi.org/10.1093/g3journal/jkac330

Ejemplares similares

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects: Distributions of fitness effects of spontaneous mutations
por: Plavskin, Yevgeniy, et al.
Publicado: (2023)

Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast
por: Lang, Gregory I., et al.
Publicado: (2013)

Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis
por: Milano, Carolyn R., et al.
Publicado: (2019)

Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1(-) Yeast Suppressed by a Dominant Mutation in ATP3
por: Li, Jing, et al.
Publicado: (2020)

Spontaneous Mutation Rates and Spectra of Respiratory-Deficient Yeast
por: Tu, Xinyu, et al.
Publicado: (2023)

The spontaneous mutation rate of Drosophila pseudoobscura
por: Krasovec, Marc
Publicado: (2021)

The Genetic Basis of Mutation Rate Variation in Yeast
por: Gou, Liangke, et al.
Publicado: (2019)

Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats
por: Villahermosa, Desirée, et al.
Publicado: (2017)

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination
por: Arlow, Tim, et al.
Publicado: (2021)

MutSβ exceeds MutSα in dinucleotide loop repair
por: Kantelinen, J, et al.
Publicado: (2010)

MutS and MutL Are Dispensable for Maintenance of the Genomic Mutation Rate in the Halophilic Archaeon Halobacterium salinarum NRC-1
por: Busch, Courtney R., et al.
Publicado: (2010)

Correlation Between Mutation Rate and Genome Size in Riboviruses: Mutation Rate of Bacteriophage Qβ
por: Bradwell, Katie, et al.
Publicado: (2013)

The Rate and Effects of Spontaneous Mutation on Fitness Traits in the Social Amoeba, Dictyostelium discoideum
por: Hall, David W., et al.
Publicado: (2013)

Noncanonical Contributions of MutLγ to VDE-Initiated Crossovers During Saccharomyces cerevisiae Meiosis
por: Shodhan, Anura, et al.
Publicado: (2019)

Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast
por: Romanova, Nina V., et al.
Publicado: (2013)

Functional Characterization and Categorization of Missense Mutations that Cause Methylmalonyl‐CoA Mutase (MUT) Deficiency
por: Forny, Patrick, et al.
Publicado: (2014)

Normal Mutation Rate Variants Arise in a Mutator (Mut S) Escherichia coli Population
por: Turrientes, María-Carmen, et al.
Publicado: (2013)

The Rate and Spectrum of Spontaneous Mutations in Mycobacterium smegmatis, a Bacterium Naturally Devoid of the Postreplicative Mismatch Repair Pathway
por: Kucukyildirim, Sibel, et al.
Publicado: (2016)

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains
por: Yamada, Masami, et al.
Publicado: (2012)

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
por: Groothuizen, Flora S, et al.
Publicado: (2015)

Yeast Models of Phosphomannomutase 2 Deficiency, a Congenital Disorder of Glycosylation
por: Lao, Jessica P., et al.
Publicado: (2018)

Correction: Normal Mutation Rate Variants Arise in a Mutator (Mut S) Escherichia coli Population
por: Turrientes, María-Carmen, et al.
Publicado: (2013)

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
por: Iyer, Ravi R., et al.
Publicado: (2010)

Genetic basis of a spontaneous mutation’s expressivity
por: Schell, Rachel, et al.
Publicado: (2022)

Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-Deficient Murine Epithelium
por: Christopher, Joseph, et al.
Publicado: (2019)

The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes
por: Garcia-Gonzalez, Aurian, et al.
Publicado: (2012)

Methylmalonic Acidemia with Novel MUT Gene Mutations
por: Panigrahi, Inusha, et al.
Publicado: (2017)

A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
por: Zhao, Xiao-Nan, et al.
Publicado: (2016)

Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant
por: Calmann, Melissa A., et al.
Publicado: (2005)

Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae
por: Krasovec, Marc, et al.
Publicado: (2016)

MutSα and MutSβ as size-dependent cellular determinants for prime editing in human embryonic stem cells
por: Park, Ju-Chan, et al.
Publicado: (2023)

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells
por: Tosti, Elena, et al.
Publicado: (2014)

Mut2Vec: distributed representation of cancerous mutations
por: Kim, Sunkyu, et al.
Publicado: (2018)

MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair
por: Yang, Xiao-Wen, et al.
Publicado: (2022)

Fine-Grained Analysis of Spontaneous Mutation Spectrum and Frequency in Arabidopsis thaliana
por: Weng, Mao-Lun, et al.
Publicado: (2019)

Quantifying Influences on Intragenomic Mutation Rate
por: Simon, Helmut, et al.
Publicado: (2020)

Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome of Dictyostelium discoideum
por: Kucukyildirim, Sibel, et al.
Publicado: (2020)

Contrasting Determinants of Mutation Rates in Germline and Soma
por: Chen, Chen, et al.
Publicado: (2017)

Functional Analysis With a Barcoder Yeast Gene Overexpression System
por: Douglas, Alison C., et al.
Publicado: (2012)

Functional Characterization of Fission Yeast Transcription Factors by Overexpression Analysis
por: Vachon, Lianne, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_cse58n1o6tar1m6flcrm50r4fp