RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells

Reactive oxygen species (ROS) levels are elevated after acquisition of resistance to v-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors including dabrafenib and MEK inhibitors such as trametinib in BRAF-mutant melanoma. To circumvent toxicity to PI-103 (a pan PI3K inhibitor), we utiliz...

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Detalles Bibliográficos
Autores principales: Patel, Hima, Mishra, Rosalin, Wier, Adam, Mokhtarpour, Nazanin, Merino, Edward J., Garrett, Joan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Pre-Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997637/
https://www.ncbi.nlm.nih.gov/pubmed/36847042
http://dx.doi.org/10.1097/CAD.0000000000001500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997637/
https://www.ncbi.nlm.nih.gov/pubmed/36847042
http://dx.doi.org/10.1097/CAD.0000000000001500

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