TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

Talin-1 is the core mechanosensitive adapter protein linking integrins to the cytoskeleton. The TLN1 gene is comprised of 57 exons that encode the 2,541 amino acid TLN1 protein. TLN1 was previously considered to be expressed as a single isoform. However, through differential pre-mRNA splicing analys...

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Detalles Bibliográficos
Autores principales: Gallego-Paez, Lina M., Edwards, William J.S., Chanduri, Manasa, Guo, Yanyu, Koorman, Thijs, Lee, Chieh-Yu, Grexa, Nina, Derksen, Patrick, Yan, Jie, Schwartz, Martin A., Mauer, Jan, Goult, Benjamin Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997659/
https://www.ncbi.nlm.nih.gov/pubmed/36880935
http://dx.doi.org/10.1083/jcb.202209010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997659/
https://www.ncbi.nlm.nih.gov/pubmed/36880935
http://dx.doi.org/10.1083/jcb.202209010

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