Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

[Image: see text] The presence of the blood–brain barrier (BBB) creates a nigh-on impenetrable obstacle for large macromolecular therapeutics that need to be delivered to the brain milieu to treat neurological disorders. To overcome this, one of the strategies used is to bypass the barrier with what...

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Detalles Bibliográficos
Autores principales: Morrison, Jamie I., Petrovic, Alex, Metzendorf, Nicole G., Rofo, Fadi, Yilmaz, Canan U., Stenler, Sofia, Laudon, Hanna, Hultqvist, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997753/
https://www.ncbi.nlm.nih.gov/pubmed/36808999
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997753/
https://www.ncbi.nlm.nih.gov/pubmed/36808999
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00768

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