Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

Speckle-type POZ protein (SPOP) is a substrate adaptor in the ubiquitin proteasome system, and plays important roles in cell-cycle control, development, and cancer pathogenesis. SPOP forms linear higher-order oligomers following an isodesmic self-association model. Oligomerization is essential for S...

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Detalles Bibliográficos
Autores principales: Thomasen, F Emil, Cuneo, Matthew J, Mittag, Tanja, Lindorff-Larsen, Kresten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998093/
https://www.ncbi.nlm.nih.gov/pubmed/36856266
http://dx.doi.org/10.7554/eLife.84147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998093/
https://www.ncbi.nlm.nih.gov/pubmed/36856266
http://dx.doi.org/10.7554/eLife.84147

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