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Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

Speckle-type POZ protein (SPOP) is a substrate adaptor in the ubiquitin proteasome system, and plays important roles in cell-cycle control, development, and cancer pathogenesis. SPOP forms linear higher-order oligomers following an isodesmic self-association model. Oligomerization is essential for S...

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Detalles Bibliográficos
Autores principales:	Thomasen, F Emil, Cuneo, Matthew J, Mittag, Tanja, Lindorff-Larsen, Kresten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998093/ https://www.ncbi.nlm.nih.gov/pubmed/36856266 http://dx.doi.org/10.7554/eLife.84147

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