Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa

Interferometric scattering (iSCAT) microscopy is a label-free optical method capable of detecting single proteins, localizing their binding positions with nanometer precision, and measuring their mass. In the ideal case, iSCAT is limited by shot noise such that collection of more photons should exte...

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Detalles Bibliográficos
Autores principales: Dahmardeh, Mahyar, Mirzaalian Dastjerdi, Houman, Mazal, Hisham, Köstler, Harald, Sandoghdar, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998267/
https://www.ncbi.nlm.nih.gov/pubmed/36849549
http://dx.doi.org/10.1038/s41592-023-01778-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998267/
https://www.ncbi.nlm.nih.gov/pubmed/36849549
http://dx.doi.org/10.1038/s41592-023-01778-2

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