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Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa
Interferometric scattering (iSCAT) microscopy is a label-free optical method capable of detecting single proteins, localizing their binding positions with nanometer precision, and measuring their mass. In the ideal case, iSCAT is limited by shot noise such that collection of more photons should exte...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998267/ https://www.ncbi.nlm.nih.gov/pubmed/36849549 http://dx.doi.org/10.1038/s41592-023-01778-2 |