Physiologically Based Pharmacokinetic Modelling to Identify Physiological and Drug Parameters Driving Pharmacokinetics in Obese Individuals

BACKGROUND: Obese individuals are often underrepresented in clinical trials, leading to a lack of dosing guidance. OBJECTIVE: This study aimed to investigate which physiological parameters and drug properties determine drug disposition changes in obese using our physiologically based pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Berton, Mattia, Bettonte, Sara, Stader, Felix, Battegay, Manuel, Marzolini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998327/
https://www.ncbi.nlm.nih.gov/pubmed/36571702
http://dx.doi.org/10.1007/s40262-022-01194-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998327/
https://www.ncbi.nlm.nih.gov/pubmed/36571702
http://dx.doi.org/10.1007/s40262-022-01194-3

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