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Physiologically Based Pharmacokinetic Modelling to Identify Physiological and Drug Parameters Driving Pharmacokinetics in Obese Individuals
BACKGROUND: Obese individuals are often underrepresented in clinical trials, leading to a lack of dosing guidance. OBJECTIVE: This study aimed to investigate which physiological parameters and drug properties determine drug disposition changes in obese using our physiologically based pharmacokinetic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998327/ https://www.ncbi.nlm.nih.gov/pubmed/36571702 http://dx.doi.org/10.1007/s40262-022-01194-3 |