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Major cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes
Epigenomic profiling, including ATACseq, is one of the main tools used to define enhancers. Because enhancers are overwhelmingly cell-type specific, inference of their activity is greatly limited in complex tissues. Multiomic assays that probe in the same nucleus both the open chromatin landscape an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998442/ https://www.ncbi.nlm.nih.gov/pubmed/36894706 http://dx.doi.org/10.1038/s41598-023-31040-w |