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Major cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes

Epigenomic profiling, including ATACseq, is one of the main tools used to define enhancers. Because enhancers are overwhelmingly cell-type specific, inference of their activity is greatly limited in complex tissues. Multiomic assays that probe in the same nucleus both the open chromatin landscape an...

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Detalles Bibliográficos
Autores principales: Leblanc, Francis J. A., Lettre, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998442/
https://www.ncbi.nlm.nih.gov/pubmed/36894706
http://dx.doi.org/10.1038/s41598-023-31040-w

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