Cargando…

A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth

Although breast cancer stem cells (BCSCs) are well characterized, molecularly targeting and eradicating this sub-population remains a challenge in the clinic. Recent studies have explored several signaling pathways that govern stem cell activation: We and others established that the Notch1 signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saran, Uttara, Chandrasekaran, Balaji, Tyagi, Ashish, Shukla, Vaibhav, Singh, Amandeep, Sharma, Arun K., Damodaran, Chendil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998682/ https://www.ncbi.nlm.nih.gov/pubmed/36909163 http://dx.doi.org/10.3389/fphar.2023.1150774

Ejemplares similares

Corrigendum: A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth
por: Saran, Uttara, et al.
Publicado: (2023)

ASR488, a novel small molecule, activates an mRNA binding protein, CPEB1, and inhibits the growth of bladder cancer
por: Tyagi, Ashish, et al.
Publicado: (2020)

Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer
por: Chandrasekaran, Balaji, et al.
Publicado: (2017)

A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis
por: Shukla, Vaibhav, et al.
Publicado: (2022)

Urolithin A analog inhibits castration-resistant prostate cancer by targeting the androgen receptor and its variant, androgen receptor-variant 7
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer
por: Pal, Deeksha, et al.
Publicado: (2018)

A Review on Notch Signaling and Colorectal Cancer
por: Tyagi, Ashish, et al.
Publicado: (2020)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells
por: Chandrasekaran, Balaji, et al.
Publicado: (2020)

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
por: Singh, Amandeep, et al.
Publicado: (2022)

Small Molecule Inhibitors of CRM1
por: Ferreira, Bibiana I., et al.
Publicado: (2020)

Novel structured ADAM17 small-molecule inhibitor represses ADAM17/Notch pathway activation and the NSCLC cells’ resistance to anti-tumour drugs
por: Chi, Meng, et al.
Publicado: (2023)

A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice
por: Purushothaman, Baskaran, et al.
Publicado: (2018)

Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy
por: Xiao, Wenjing, et al.
Publicado: (2021)

Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment
por: Zheng, Xiaohang, et al.
Publicado: (2022)

Identification of a potent herbal molecule for the treatment of breast cancer
por: Koduru, Srinivas, et al.
Publicado: (2009)

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond
por: Davidson, David, et al.
Publicado: (2013)

Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
por: Liu, Yanan, et al.
Publicado: (2021)

A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic Reticulum Stress
por: Correia da Silva, Daniela, et al.
Publicado: (2022)

Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors
por: Arullampalam, Prakash, et al.
Publicado: (2021)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
por: Du, Yue, et al.
Publicado: (2022)

Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective
por: Zheng, Wenyue, et al.
Publicado: (2022)

Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors
por: Hoffman, Charles S.
Publicado: (2022)

Study on the Characteristics of Small-Molecule Kinase Inhibitors-Related Drug-Induced Liver Injury
por: Dong, Huiqun, et al.
Publicado: (2022)

Small-molecule inhibitors of kinases in breast cancer therapy: recent advances, opportunities, and challenges
por: Bansal, Isha, et al.
Publicado: (2023)

Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
por: Meurer, Steffen K., et al.
Publicado: (2018)

Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production
por: Poksay, Karen S., et al.
Publicado: (2017)

A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors
por: Jin, Ying, et al.
Publicado: (2020)

Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!
por: Pollet, Marius, et al.
Publicado: (2018)

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
por: Sen, Edanur, et al.
Publicado: (2021)

Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo
por: Su, Tao, et al.
Publicado: (2018)

Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
por: Suman, Suman, et al.
Publicado: (2016)

Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
por: Hurtado, Cecilia, et al.
Publicado: (2019)

Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2
por: Li, Shufen, et al.
Publicado: (2021)

Phase I pharmacokinetic study of an oral, small-molecule MEK inhibitor tunlametinib in patients with advanced NRAS mutant melanoma
por: Zhao, Qian, et al.
Publicado: (2022)

Editorial: DNA & RNA methylation: impact on cancer progression
por: Shukla, Vaibhav, et al.
Publicado: (2023)

Editorial: Targeting autophagy in Cancer Therapy: Focus on small-molecule modulators and new strategies
por: Pluta, Ryszard
Publicado: (2023)

ToxiM: A Toxicity Prediction Tool for Small Molecules Developed Using Machine Learning and Chemoinformatics Approaches
por: Sharma, Ashok K., et al.
Publicado: (2017)

Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists
por: Pérez-Jeldres, Tamara, et al.
Publicado: (2019)

9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells
por: Poloznikov, Andrey, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eeotttf8a208dqmso5iithv18a