In a secondary analysis from a randomised, double-blind placebo-controlled trial Dexmedetomidine blocks cholinergic dysregulation in delirium pathogenesis in patients with major surgery

Dexmedetomidine is an alpha-2 adrenoreceptor agonist with anti-inflammatory and anti-delirogenic properties. Pathogenesis of postoperative delirium (POD) includes cholinergic dysfunction and deregulated inflammatory response to surgical trauma. Acetylcholinesterase (AChE) and butyrylcholinesterase (...

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Detalles Bibliográficos
Autores principales: Jacob, Yanite, Schneider, Bill, Spies, Claudia, Heinrich, Maria, von Haefen, Clarissa, Kho, Widuri, Pohrt, Anne, Müller, Anika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998872/
https://www.ncbi.nlm.nih.gov/pubmed/36894596
http://dx.doi.org/10.1038/s41598-023-30756-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998872/
https://www.ncbi.nlm.nih.gov/pubmed/36894596
http://dx.doi.org/10.1038/s41598-023-30756-z

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