Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance

Acquired chemoresistance to proteasome inhibitors is a major obstacle in managing multiple myeloma but key regulators and underlying mechanisms still remain to be explored. We find that high level of HP1γ is associated with low acetylation modification in the bortezomib-resistant myeloma cells using...

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Detalles Bibliográficos
Autores principales: Li, Xin, Wang, Sheng, Xie, Ying, Jiang, Hongmei, Guo, Jing, Wang, Yixuan, Peng, Ziyi, Hu, Meilin, Wang, Mengqi, Wang, Jingya, Li, Qian, Wang, Yafei, Liu, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998874/
https://www.ncbi.nlm.nih.gov/pubmed/36894562
http://dx.doi.org/10.1038/s41467-023-37013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998874/
https://www.ncbi.nlm.nih.gov/pubmed/36894562
http://dx.doi.org/10.1038/s41467-023-37013-x

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