A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hamster ovary (CHO) cells to produce α-galactosidase A...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yen-Hsi, Tian, Weihua, Yasuda, Makiko, Ye, Zilu, Song, Ming, Mandel, Ulla, Kristensen, Claus, Povolo, Lorenzo, Marques, André R. A., Čaval, Tomislav, Heck, Albert J. R., Sampaio, Julio Lopes, Johannes, Ludger, Tsukimura, Takahiro, Desnick, Robert, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999025/
https://www.ncbi.nlm.nih.gov/pubmed/36911201
http://dx.doi.org/10.3389/fbioe.2023.1128371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999025/
https://www.ncbi.nlm.nih.gov/pubmed/36911201
http://dx.doi.org/10.3389/fbioe.2023.1128371

Ejemplares similares