Genes Vary Greatly in Their Propensity for Collateral Fitness Effects of Mutations

Mutations can have deleterious fitness effects when they decrease protein specific activity or decrease active protein abundance. Mutations will also be deleterious when they cause misfolding or misinteractions that are toxic to the cell (i.e., independent of whether the mutations affect specific ac...

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Detalles Bibliográficos
Autores principales: Mehlhoff, Jacob D, Ostermeier, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999109/
https://www.ncbi.nlm.nih.gov/pubmed/36798991
http://dx.doi.org/10.1093/molbev/msad038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999109/
https://www.ncbi.nlm.nih.gov/pubmed/36798991
http://dx.doi.org/10.1093/molbev/msad038

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