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Genes Vary Greatly in Their Propensity for Collateral Fitness Effects of Mutations
Mutations can have deleterious fitness effects when they decrease protein specific activity or decrease active protein abundance. Mutations will also be deleterious when they cause misfolding or misinteractions that are toxic to the cell (i.e., independent of whether the mutations affect specific ac...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999109/ https://www.ncbi.nlm.nih.gov/pubmed/36798991 http://dx.doi.org/10.1093/molbev/msad038 |