Examination of early treatment effects and related biases during the conduct of two UK-wide pragmatic orthopaedic surgical trials: ProFHER and UK FROST

AIMS: Early large treatment effects can arise in small studies, which lessen as more data accumulate. This study aimed to retrospectively examine whether early treatment effects occurred for two multicentre orthopaedic randomized controlled trials (RCTs) and explore biases related to this. METHODS:...

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Detalles Bibliográficos
Autores principales: Knowlson, Catherine N., Brealey, Stephen, Keding, Ada, Torgerson, David, Rangan, Amar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Editorial Society of Bone & Joint Surgery 2023
Materias:
General Orthopaedics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999120/
https://www.ncbi.nlm.nih.gov/pubmed/37051861
http://dx.doi.org/10.1302/2633-1462.42.BJO-2022-0139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999120/
https://www.ncbi.nlm.nih.gov/pubmed/37051861
http://dx.doi.org/10.1302/2633-1462.42.BJO-2022-0139

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