3D geometry orchestrates the transcriptional landscape of metastatic neuroblastoma cells in a multicellular in vitro bone model

A key challenge for the discovery of novel molecular targets and therapeutics against pediatric bone metastatic disease is the lack of bona fide in vitro cell models. Here, we show that a beta-tricalcium phosphate (β-TCP) multicellular 3D in vitro bone microtissue model reconstitutes key phenotypic...

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Detalles Bibliográficos
Autores principales: Nasehi, Ramin, Abdallah, Ali T., Pantile, Marcella, Zanon, Carlo, Vogt, Michael, Rütten, Stephan, Fischer, Horst, Aveic, Sanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999213/
https://www.ncbi.nlm.nih.gov/pubmed/36910273
http://dx.doi.org/10.1016/j.mtbio.2023.100596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999213/
https://www.ncbi.nlm.nih.gov/pubmed/36910273
http://dx.doi.org/10.1016/j.mtbio.2023.100596

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