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PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats

Epidemiological and animal studies indicate that pre-existing diabetes increases the risk of Parkinson's disease (PD). However, the mechanisms underlying this association remain unclear. In the present study, we found that high glucose (HG) levels in the cerebrospinal fluid (CSF) of diabetic ra...

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Detalles Bibliográficos
Autores principales: Zhao, Ya, Wang, Yanwei, Wu, Yuying, Tao, Cimin, Xu, Rui, Chen, Yong, Qian, Linghui, Xu, Tengfei, Lian, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999299/
https://www.ncbi.nlm.nih.gov/pubmed/36908857
http://dx.doi.org/10.1016/j.jpha.2022.11.006