Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones

[Image: see text] Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction of the morphan core via a palladium/hydroxy proline co-catalyzed desymmetrization of vinyl-bromide-tethered cyclohexano...

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Detalles Bibliográficos
Autores principales: Kučera, Roman, Ellis, Sam R., Yamazaki, Ken, Hayward Cooke, Jack, Chekshin, Nikita, Christensen, Kirsten E., Hamlin, Trevor A., Dixon, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999414/
https://www.ncbi.nlm.nih.gov/pubmed/36820616
http://dx.doi.org/10.1021/jacs.2c13710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999414/
https://www.ncbi.nlm.nih.gov/pubmed/36820616
http://dx.doi.org/10.1021/jacs.2c13710

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