Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats

An age-associated decrease in N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic function contributes to impaired synaptic plasticity and is associated with cognitive impairments. Levels of serine racemase (SR), an enzyme that synthesizes D-serine, an NMDAR co-agonist, decline with age. Thus, e...

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Detalles Bibliográficos
Autores principales: Yegla, Brittney, Rani, Asha, Kumar, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120901/
https://www.ncbi.nlm.nih.gov/pubmed/37052995
http://dx.doi.org/10.18632/aging.204652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120901/
https://www.ncbi.nlm.nih.gov/pubmed/37052995
http://dx.doi.org/10.18632/aging.204652

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