Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis

[Image: see text] Three new benzo[b]naphtho[2,1-d]furans, usambarins A–C (1–3), five new 2-phenylnaphthalenes, usambarins D–H (4–8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usamba...

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Autores principales: Chepkirui, Carolyne, Ali Adem, Fozia, Rudenko, Anastasia, Gütlin, Yukino, Ndakala, Albert, Derese, Solomon, Orthaber, Andreas, Bourgard, Catarina, Yenesew, Abiy, Erdélyi, Máté
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152483/
https://www.ncbi.nlm.nih.gov/pubmed/37043719
http://dx.doi.org/10.1021/acs.jnatprod.3c00051
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author Chepkirui, Carolyne
Ali Adem, Fozia
Rudenko, Anastasia
Gütlin, Yukino
Ndakala, Albert
Derese, Solomon
Orthaber, Andreas
Bourgard, Catarina
Yenesew, Abiy
Erdélyi, Máté
author_facet Chepkirui, Carolyne
Ali Adem, Fozia
Rudenko, Anastasia
Gütlin, Yukino
Ndakala, Albert
Derese, Solomon
Orthaber, Andreas
Bourgard, Catarina
Yenesew, Abiy
Erdélyi, Máté
author_sort Chepkirui, Carolyne
collection PubMed
description [Image: see text] Three new benzo[b]naphtho[2,1-d]furans, usambarins A–C (1–3), five new 2-phenylnaphthalenes, usambarins D–H (4–8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usambarensis (Moraceae). The structures were deduced using NMR spectroscopic and mass spectrometric analyses, and those of compounds 1 and 4 were confirmed by X-ray crystallography. Usambarin D (4) demonstrated moderate antibacterial activity (MIC 9.0 μM) against Bacillus subtilis, while none of the tested compounds were effective against Escherichia coli.
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spelling pubmed-101524832023-05-03 Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis Chepkirui, Carolyne Ali Adem, Fozia Rudenko, Anastasia Gütlin, Yukino Ndakala, Albert Derese, Solomon Orthaber, Andreas Bourgard, Catarina Yenesew, Abiy Erdélyi, Máté J Nat Prod [Image: see text] Three new benzo[b]naphtho[2,1-d]furans, usambarins A–C (1–3), five new 2-phenylnaphthalenes, usambarins D–H (4–8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usambarensis (Moraceae). The structures were deduced using NMR spectroscopic and mass spectrometric analyses, and those of compounds 1 and 4 were confirmed by X-ray crystallography. Usambarin D (4) demonstrated moderate antibacterial activity (MIC 9.0 μM) against Bacillus subtilis, while none of the tested compounds were effective against Escherichia coli. American Chemical Society and American Society of Pharmacognosy 2023-04-12 /pmc/articles/PMC10152483/ /pubmed/37043719 http://dx.doi.org/10.1021/acs.jnatprod.3c00051 Text en © 2023 The Authors. Published by American Chemical Society and American Society of Pharmacognosy https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Chepkirui, Carolyne
Ali Adem, Fozia
Rudenko, Anastasia
Gütlin, Yukino
Ndakala, Albert
Derese, Solomon
Orthaber, Andreas
Bourgard, Catarina
Yenesew, Abiy
Erdélyi, Máté
Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title_full Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title_fullStr Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title_full_unstemmed Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title_short Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
title_sort benzo[b]naphtho[2,1-d]furans and 2-phenylnaphthalenes from streblus usambarensis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152483/
https://www.ncbi.nlm.nih.gov/pubmed/37043719
http://dx.doi.org/10.1021/acs.jnatprod.3c00051
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