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Genetic bases of language control in bilinguals: Evidence from an EEG study

Previous studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of their experiences switching between languages or whether it is a specific, yet highly‐adaptive, cognitive ability. The current study investigates how variations in the language‐re...

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Autores principales: Liu, Dongxue, Xing, Zehui, Huang, Junjun, Schwieter, John W., Liu, Huanhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203802/
https://www.ncbi.nlm.nih.gov/pubmed/37051723
http://dx.doi.org/10.1002/hbm.26301
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author Liu, Dongxue
Xing, Zehui
Huang, Junjun
Schwieter, John W.
Liu, Huanhuan
author_facet Liu, Dongxue
Xing, Zehui
Huang, Junjun
Schwieter, John W.
Liu, Huanhuan
author_sort Liu, Dongxue
collection PubMed
description Previous studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of their experiences switching between languages or whether it is a specific, yet highly‐adaptive, cognitive ability. The current study investigates how variations in the language‐related gene FOXP2 and executive function‐related genes COMT, BDNF, and Kibra/WWC1 affect bilingual language control during two phases of speech production, namely the language schema phase (i.e., the selection of one language or another) and lexical response phase (i.e., utterance of the target). Chinese–English bilinguals (N = 119) participated in a picture‐naming task involving cued language switches. Statistical analyses showed that both genes significantly influenced language control on neural coding and behavioral performance. Specifically, FOXP2 rs1456031 showed a wide‐ranging effect on language control, including RTs, F(2, 113) = 4.00, FDR p = .036, and neural coding across three‐time phases (N2a: F(2, 113) = 4.96, FDR p = .014; N2b: F(2, 113) = 4.30, FDR p = .028, LPC: F(2, 113) = 2.82, FDR p = .060), while the COMT rs4818 (ts >2.69, FDR ps < .05), BDNF rs6265 (Fs >5.31, FDR ps < .05), and Kibra/WWC1 rs17070145 (ts > −3.29, FDR ps < .05) polymorphisms influenced two‐time phases (N2a and N2b). Time‐resolved correlation analyses revealed that the relationship between neural coding and cognitive performance is modulated by genetic variations in all four genes. In all, these findings suggest that bilingual language control is shaped by an individual's experience switching between languages and their inherent genome.
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spelling pubmed-102038022023-05-24 Genetic bases of language control in bilinguals: Evidence from an EEG study Liu, Dongxue Xing, Zehui Huang, Junjun Schwieter, John W. Liu, Huanhuan Hum Brain Mapp Research Articles Previous studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of their experiences switching between languages or whether it is a specific, yet highly‐adaptive, cognitive ability. The current study investigates how variations in the language‐related gene FOXP2 and executive function‐related genes COMT, BDNF, and Kibra/WWC1 affect bilingual language control during two phases of speech production, namely the language schema phase (i.e., the selection of one language or another) and lexical response phase (i.e., utterance of the target). Chinese–English bilinguals (N = 119) participated in a picture‐naming task involving cued language switches. Statistical analyses showed that both genes significantly influenced language control on neural coding and behavioral performance. Specifically, FOXP2 rs1456031 showed a wide‐ranging effect on language control, including RTs, F(2, 113) = 4.00, FDR p = .036, and neural coding across three‐time phases (N2a: F(2, 113) = 4.96, FDR p = .014; N2b: F(2, 113) = 4.30, FDR p = .028, LPC: F(2, 113) = 2.82, FDR p = .060), while the COMT rs4818 (ts >2.69, FDR ps < .05), BDNF rs6265 (Fs >5.31, FDR ps < .05), and Kibra/WWC1 rs17070145 (ts > −3.29, FDR ps < .05) polymorphisms influenced two‐time phases (N2a and N2b). Time‐resolved correlation analyses revealed that the relationship between neural coding and cognitive performance is modulated by genetic variations in all four genes. In all, these findings suggest that bilingual language control is shaped by an individual's experience switching between languages and their inherent genome. John Wiley & Sons, Inc. 2023-04-13 /pmc/articles/PMC10203802/ /pubmed/37051723 http://dx.doi.org/10.1002/hbm.26301 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Liu, Dongxue
Xing, Zehui
Huang, Junjun
Schwieter, John W.
Liu, Huanhuan
Genetic bases of language control in bilinguals: Evidence from an EEG study
title Genetic bases of language control in bilinguals: Evidence from an EEG study
title_full Genetic bases of language control in bilinguals: Evidence from an EEG study
title_fullStr Genetic bases of language control in bilinguals: Evidence from an EEG study
title_full_unstemmed Genetic bases of language control in bilinguals: Evidence from an EEG study
title_short Genetic bases of language control in bilinguals: Evidence from an EEG study
title_sort genetic bases of language control in bilinguals: evidence from an eeg study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203802/
https://www.ncbi.nlm.nih.gov/pubmed/37051723
http://dx.doi.org/10.1002/hbm.26301
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