XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS

OBJECTIVE: To analyze the efficacy and prognosticators of pediatric diffuse intrinsic pontine glioma (DPC) treated with re-irradiation. METHODS: The clinical data and prognostic information of DIPG children younger than 18 years old who received re-irradiation in the Department of Oncology of Guangd...

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Autores principales: Cai, Linbo, Lai, Mingyao, Li, Juan, Zhou, Jiangfen, Li, Shaoqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260086/
http://dx.doi.org/10.1093/neuonc/noad073.299
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author Cai, Linbo
Lai, Mingyao
Li, Juan
Zhou, Jiangfen
Li, Shaoqun
author_facet Cai, Linbo
Lai, Mingyao
Li, Juan
Zhou, Jiangfen
Li, Shaoqun
author_sort Cai, Linbo
collection PubMed
description OBJECTIVE: To analyze the efficacy and prognosticators of pediatric diffuse intrinsic pontine glioma (DPC) treated with re-irradiation. METHODS: The clinical data and prognostic information of DIPG children younger than 18 years old who received re-irradiation in the Department of Oncology of Guangdong Sanjiu Brain Hospital from May 1, 2021, to November 1, 2022, were collected. The overall survival (OS) was calculated, and univariate analysis was performed to analyze the effect of tumor volume change and rate of change on survival. RESULTS: Fifteen patients met the inclusion criteria. The median interval between the first and second radiotherapy was 8.8 months. The median survival after re-irradiation was 3.9 months, and the median overall survival was 16.9 months. Severe complications such as fatal radiation brain necrosis was observed after re-irradiation. CONCLUSIONS: Re-irradiation is still the primary treatment for pediatric diffuse intrinsic pontine glioma, prolonging their survival.
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spelling pubmed-102600862023-06-13 XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS Cai, Linbo Lai, Mingyao Li, Juan Zhou, Jiangfen Li, Shaoqun Neuro Oncol Final Category: Radiation Oncology - XRT OBJECTIVE: To analyze the efficacy and prognosticators of pediatric diffuse intrinsic pontine glioma (DPC) treated with re-irradiation. METHODS: The clinical data and prognostic information of DIPG children younger than 18 years old who received re-irradiation in the Department of Oncology of Guangdong Sanjiu Brain Hospital from May 1, 2021, to November 1, 2022, were collected. The overall survival (OS) was calculated, and univariate analysis was performed to analyze the effect of tumor volume change and rate of change on survival. RESULTS: Fifteen patients met the inclusion criteria. The median interval between the first and second radiotherapy was 8.8 months. The median survival after re-irradiation was 3.9 months, and the median overall survival was 16.9 months. Severe complications such as fatal radiation brain necrosis was observed after re-irradiation. CONCLUSIONS: Re-irradiation is still the primary treatment for pediatric diffuse intrinsic pontine glioma, prolonging their survival. Oxford University Press 2023-06-12 /pmc/articles/PMC10260086/ http://dx.doi.org/10.1093/neuonc/noad073.299 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Final Category: Radiation Oncology - XRT
Cai, Linbo
Lai, Mingyao
Li, Juan
Zhou, Jiangfen
Li, Shaoqun
XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title_full XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title_fullStr XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title_full_unstemmed XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title_short XRT-03. EFFICACY OF RE-IRRADIATION FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMAS
title_sort xrt-03. efficacy of re-irradiation for pediatric diffuse intrinsic pontine gliomas
topic Final Category: Radiation Oncology - XRT
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260086/
http://dx.doi.org/10.1093/neuonc/noad073.299
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