Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds

Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date are pan-HDAC inhibitors and most show a poor selectivity profile, side effects, and in particular hydroxamic-acid-based inhibitors lack good...

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Detalles Bibliográficos
Autores principales: Bülbül, Emre F., Robaa, Dina, Sun, Ping, Mahmoudi, Fereshteh, Melesina, Jelena, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386743/
https://www.ncbi.nlm.nih.gov/pubmed/37513880
http://dx.doi.org/10.3390/ph16070968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386743/
https://www.ncbi.nlm.nih.gov/pubmed/37513880
http://dx.doi.org/10.3390/ph16070968

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