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Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review

BACKGROUND: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the e...

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Autores principales: Bodhini, Dhanasekaran, Morton, Robert W., Santhakumar, Vanessa, Nakabuye, Mariam, Pomares-Millan, Hugo, Clemmensen, Christoffer, Fitzpatrick, Stephanie L., Guasch-Ferre, Marta, Pankow, James S., Ried-Larsen, Mathias, Franks, Paul W., Tobias, Deirdre K., Merino, Jordi, Mohan, Viswanathan, Loos, Ruth J. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551013/
https://www.ncbi.nlm.nih.gov/pubmed/37794109
http://dx.doi.org/10.1038/s43856-023-00363-0
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author Bodhini, Dhanasekaran
Morton, Robert W.
Santhakumar, Vanessa
Nakabuye, Mariam
Pomares-Millan, Hugo
Clemmensen, Christoffer
Fitzpatrick, Stephanie L.
Guasch-Ferre, Marta
Pankow, James S.
Ried-Larsen, Mathias
Franks, Paul W.
Tobias, Deirdre K.
Merino, Jordi
Mohan, Viswanathan
Loos, Ruth J. F.
author_facet Bodhini, Dhanasekaran
Morton, Robert W.
Santhakumar, Vanessa
Nakabuye, Mariam
Pomares-Millan, Hugo
Clemmensen, Christoffer
Fitzpatrick, Stephanie L.
Guasch-Ferre, Marta
Pankow, James S.
Ried-Larsen, Mathias
Franks, Paul W.
Tobias, Deirdre K.
Merino, Jordi
Mohan, Viswanathan
Loos, Ruth J. F.
author_sort Bodhini, Dhanasekaran
collection PubMed
description BACKGROUND: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. METHODS: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. RESULTS: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. CONCLUSIONS: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
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spelling pubmed-105510132023-10-06 Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review Bodhini, Dhanasekaran Morton, Robert W. Santhakumar, Vanessa Nakabuye, Mariam Pomares-Millan, Hugo Clemmensen, Christoffer Fitzpatrick, Stephanie L. Guasch-Ferre, Marta Pankow, James S. Ried-Larsen, Mathias Franks, Paul W. Tobias, Deirdre K. Merino, Jordi Mohan, Viswanathan Loos, Ruth J. F. Commun Med (Lond) Article BACKGROUND: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. METHODS: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. RESULTS: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. CONCLUSIONS: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies. Nature Publishing Group UK 2023-10-05 /pmc/articles/PMC10551013/ /pubmed/37794109 http://dx.doi.org/10.1038/s43856-023-00363-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bodhini, Dhanasekaran
Morton, Robert W.
Santhakumar, Vanessa
Nakabuye, Mariam
Pomares-Millan, Hugo
Clemmensen, Christoffer
Fitzpatrick, Stephanie L.
Guasch-Ferre, Marta
Pankow, James S.
Ried-Larsen, Mathias
Franks, Paul W.
Tobias, Deirdre K.
Merino, Jordi
Mohan, Viswanathan
Loos, Ruth J. F.
Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title_full Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title_fullStr Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title_full_unstemmed Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title_short Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
title_sort impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551013/
https://www.ncbi.nlm.nih.gov/pubmed/37794109
http://dx.doi.org/10.1038/s43856-023-00363-0
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