p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes

Mice with a constitutive increase in p53 activity exhibited features of dyskeratosis congenita (DC), a bone marrow failure syndrome (BMFS) caused by defective telomere maintenance. Further studies confirmed, in humans and mice, that germline mutations affecting TP53 or its regulator MDM4 may cause s...

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Detalles Bibliográficos
Autores principales: Rakotopare, Jeanne, Toledo, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573108/
https://www.ncbi.nlm.nih.gov/pubmed/37834388
http://dx.doi.org/10.3390/ijms241914940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573108/
https://www.ncbi.nlm.nih.gov/pubmed/37834388
http://dx.doi.org/10.3390/ijms241914940

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