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Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats

Liver injury is a prevalent pathological process that can give rise to conditions such as fatty liver, cirrhosis, fibrosis, and even cancer. It has been observed that plants and natural products possess significant protective effects against liver injury. Current study was performed to investigate t...

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Autores principales: Zahira, Andleeb, Sultana, Salma, Rasul, Azhar, Sultana, Tayyaba, Hassan, Mudassir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618483/
https://www.ncbi.nlm.nih.gov/pubmed/37920798
http://dx.doi.org/10.1016/j.sjbs.2023.103811
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author Zahira, Andleeb
Sultana, Salma
Rasul, Azhar
Sultana, Tayyaba
Hassan, Mudassir
author_facet Zahira, Andleeb
Sultana, Salma
Rasul, Azhar
Sultana, Tayyaba
Hassan, Mudassir
author_sort Zahira, Andleeb
collection PubMed
description Liver injury is a prevalent pathological process that can give rise to conditions such as fatty liver, cirrhosis, fibrosis, and even cancer. It has been observed that plants and natural products possess significant protective effects against liver injury. Current study was performed to investigate the efficacy of almonds shell against carbon tetrachloride (CCl(4)) induced hepatotoxicity in rat model. As almonds shell contain a large variety of phenolic and flavonoid compounds, which are largely associated with antioxidant and hepatoprotective properties. For this purpose, screening of small-scale library of twenty plant extracts was performed for evaluation of antioxidant potential by DPPH assay. The data revealed that almonds shell extract (ASEE) exhibited potent antioxidant activity. This potent extract was further evaluated for hepatoprotective activity in in vivo rat model on 30 rats, divided into 6 groups of 5 rats each. On 29th day all rats were sacrificed and blood serum was collected for further analysis. Liver tissues were also preserved in formalin for histopathology. The results demonstrated that ASEE displayed a protective effect on liver function tests (LFT), renal function tests (RFT), and lipid biomarkers in comparison to the CCl4 group. The histological data also unveiled a substantial safeguarding impact on liver damage, characterized by a reduction in apoptosis, diminished liver hemorrhage, and decreased accumulation of cellular debris. The data indicates that ethanolic extract from almond shells possesses hepatoprotective potential, suggesting its viability as an alternative source for hepatoprotective drug development after pre-clinical research.
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spelling pubmed-106184832023-11-02 Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats Zahira, Andleeb Sultana, Salma Rasul, Azhar Sultana, Tayyaba Hassan, Mudassir Saudi J Biol Sci Original Article Liver injury is a prevalent pathological process that can give rise to conditions such as fatty liver, cirrhosis, fibrosis, and even cancer. It has been observed that plants and natural products possess significant protective effects against liver injury. Current study was performed to investigate the efficacy of almonds shell against carbon tetrachloride (CCl(4)) induced hepatotoxicity in rat model. As almonds shell contain a large variety of phenolic and flavonoid compounds, which are largely associated with antioxidant and hepatoprotective properties. For this purpose, screening of small-scale library of twenty plant extracts was performed for evaluation of antioxidant potential by DPPH assay. The data revealed that almonds shell extract (ASEE) exhibited potent antioxidant activity. This potent extract was further evaluated for hepatoprotective activity in in vivo rat model on 30 rats, divided into 6 groups of 5 rats each. On 29th day all rats were sacrificed and blood serum was collected for further analysis. Liver tissues were also preserved in formalin for histopathology. The results demonstrated that ASEE displayed a protective effect on liver function tests (LFT), renal function tests (RFT), and lipid biomarkers in comparison to the CCl4 group. The histological data also unveiled a substantial safeguarding impact on liver damage, characterized by a reduction in apoptosis, diminished liver hemorrhage, and decreased accumulation of cellular debris. The data indicates that ethanolic extract from almond shells possesses hepatoprotective potential, suggesting its viability as an alternative source for hepatoprotective drug development after pre-clinical research. Elsevier 2023-11 2023-09-14 /pmc/articles/PMC10618483/ /pubmed/37920798 http://dx.doi.org/10.1016/j.sjbs.2023.103811 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Zahira, Andleeb
Sultana, Salma
Rasul, Azhar
Sultana, Tayyaba
Hassan, Mudassir
Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title_full Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title_fullStr Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title_full_unstemmed Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title_short Hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
title_sort hepatoprotective effects of almond shells against carbon tetrachloride induced liver injury in albino rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618483/
https://www.ncbi.nlm.nih.gov/pubmed/37920798
http://dx.doi.org/10.1016/j.sjbs.2023.103811
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