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Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc...

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Autores principales: Rodriguez-Martin, Inmaculada, Villanueva-Martin, Gonzalo, Guillen-Del-Castillo, Alfredo, Ortego-Centeno, Norberto, Callejas, José L., Simeón-Aznar, Carmen P., Martin, Javier, Acosta-Herrera, Marialbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648506/
https://www.ncbi.nlm.nih.gov/pubmed/37958573
http://dx.doi.org/10.3390/ijms242115589
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author Rodriguez-Martin, Inmaculada
Villanueva-Martin, Gonzalo
Guillen-Del-Castillo, Alfredo
Ortego-Centeno, Norberto
Callejas, José L.
Simeón-Aznar, Carmen P.
Martin, Javier
Acosta-Herrera, Marialbert
author_facet Rodriguez-Martin, Inmaculada
Villanueva-Martin, Gonzalo
Guillen-Del-Castillo, Alfredo
Ortego-Centeno, Norberto
Callejas, José L.
Simeón-Aznar, Carmen P.
Martin, Javier
Acosta-Herrera, Marialbert
author_sort Rodriguez-Martin, Inmaculada
collection PubMed
description Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528–0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563–0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc.
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spelling pubmed-106485062023-10-25 Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study Rodriguez-Martin, Inmaculada Villanueva-Martin, Gonzalo Guillen-Del-Castillo, Alfredo Ortego-Centeno, Norberto Callejas, José L. Simeón-Aznar, Carmen P. Martin, Javier Acosta-Herrera, Marialbert Int J Mol Sci Communication Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528–0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563–0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc. MDPI 2023-10-25 /pmc/articles/PMC10648506/ /pubmed/37958573 http://dx.doi.org/10.3390/ijms242115589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Rodriguez-Martin, Inmaculada
Villanueva-Martin, Gonzalo
Guillen-Del-Castillo, Alfredo
Ortego-Centeno, Norberto
Callejas, José L.
Simeón-Aznar, Carmen P.
Martin, Javier
Acosta-Herrera, Marialbert
Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title_full Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title_fullStr Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title_full_unstemmed Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title_short Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
title_sort contribution of telomere length to systemic sclerosis onset: a mendelian randomization study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648506/
https://www.ncbi.nlm.nih.gov/pubmed/37958573
http://dx.doi.org/10.3390/ijms242115589
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