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Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study
Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648506/ https://www.ncbi.nlm.nih.gov/pubmed/37958573 http://dx.doi.org/10.3390/ijms242115589 |
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author | Rodriguez-Martin, Inmaculada Villanueva-Martin, Gonzalo Guillen-Del-Castillo, Alfredo Ortego-Centeno, Norberto Callejas, José L. Simeón-Aznar, Carmen P. Martin, Javier Acosta-Herrera, Marialbert |
author_facet | Rodriguez-Martin, Inmaculada Villanueva-Martin, Gonzalo Guillen-Del-Castillo, Alfredo Ortego-Centeno, Norberto Callejas, José L. Simeón-Aznar, Carmen P. Martin, Javier Acosta-Herrera, Marialbert |
author_sort | Rodriguez-Martin, Inmaculada |
collection | PubMed |
description | Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528–0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563–0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc. |
format | Online Article Text |
id | pubmed-10648506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106485062023-10-25 Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study Rodriguez-Martin, Inmaculada Villanueva-Martin, Gonzalo Guillen-Del-Castillo, Alfredo Ortego-Centeno, Norberto Callejas, José L. Simeón-Aznar, Carmen P. Martin, Javier Acosta-Herrera, Marialbert Int J Mol Sci Communication Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528–0.970], p = 0.031) and the Mendelian randomization pleiotropy residual sum and outlier method (OR = 0.716 [95% CI 0.563–0.911], p = 0.035) indicate an association between telomere length and SSc. Specifically, longer genetically predicted LTL is associated with a reduced risk of SSc. Sensitivity tests highlight the significant roles of the variants rs10936599 and rs2736100 annotated to the TERC and TERT genes, respectively. Our findings suggest an influence of telomere length in leukocytes on the development of SSc. MDPI 2023-10-25 /pmc/articles/PMC10648506/ /pubmed/37958573 http://dx.doi.org/10.3390/ijms242115589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Rodriguez-Martin, Inmaculada Villanueva-Martin, Gonzalo Guillen-Del-Castillo, Alfredo Ortego-Centeno, Norberto Callejas, José L. Simeón-Aznar, Carmen P. Martin, Javier Acosta-Herrera, Marialbert Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title | Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title_full | Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title_fullStr | Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title_full_unstemmed | Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title_short | Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study |
title_sort | contribution of telomere length to systemic sclerosis onset: a mendelian randomization study |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648506/ https://www.ncbi.nlm.nih.gov/pubmed/37958573 http://dx.doi.org/10.3390/ijms242115589 |
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