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PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS

Guinea pig 7Sγ(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for...

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Detalles Bibliográficos
Autores principales: Ovary, Zoltan, Benacerraf, Baruj, Bloch, Kurt J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137601/
https://www.ncbi.nlm.nih.gov/pubmed/13940786
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author Ovary, Zoltan
Benacerraf, Baruj
Bloch, Kurt J.
author_facet Ovary, Zoltan
Benacerraf, Baruj
Bloch, Kurt J.
author_sort Ovary, Zoltan
collection PubMed
description Guinea pig 7Sγ(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.
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spelling pubmed-21376012008-04-17 PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS Ovary, Zoltan Benacerraf, Baruj Bloch, Kurt J. J Exp Med Article Guinea pig 7Sγ(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites. The Rockefeller University Press 1963-06-01 /pmc/articles/PMC2137601/ /pubmed/13940786 Text en Copyright ©, 1963, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ovary, Zoltan
Benacerraf, Baruj
Bloch, Kurt J.
PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title_full PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title_fullStr PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title_full_unstemmed PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title_short PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS
title_sort properties of guinea pig 7s antibodies : ii. identification of antibodies involved in passive cutaneous and systemic anaphylaxis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137601/
https://www.ncbi.nlm.nih.gov/pubmed/13940786
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