An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor

Down-regulation of activated and ubiquitinated growth factor (GF) receptors by endocytosis and subsequent lysosomal degradation ensures attenuation of GF signaling. The ubiquitin-binding adaptor protein Eps15 (epidermal growth factor receptor [EGFR] pathway substrate 15) functions in endocytosis of...

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Detalles Bibliográficos
Autores principales: Roxrud, Ingrid, Raiborg, Camilla, Pedersen, Nina Marie, Stang, Espen, Stenmark, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373575/
https://www.ncbi.nlm.nih.gov/pubmed/18362181
http://dx.doi.org/10.1083/jcb.200708115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373575/
https://www.ncbi.nlm.nih.gov/pubmed/18362181
http://dx.doi.org/10.1083/jcb.200708115

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