PPARα in Obesity: Sex Difference and Estrogen Involvement

Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for li...

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Autor principal: Yoon, Michung
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943125/
https://www.ncbi.nlm.nih.gov/pubmed/20871824
http://dx.doi.org/10.1155/2010/584296
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author Yoon, Michung
author_facet Yoon, Michung
author_sort Yoon, Michung
collection PubMed
description Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for lipid and lipoprotein metabolism. PPARα activators are further shown to reduce body weight gain and adiposity, at least in part, due to the increase of hepatic fatty acid oxidation and the decrease in levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of the PPARα ligand fenofibrate on obesity are regulated with sexual dimorphism and seem to be influenced by the presence of functioning ovaries, suggesting the involvement of ovarian steroids in the control of obesity by PPARα. In female ovariectomized mice, 17β-estradiol inhibits the actions of fenofibrate on obesity through its suppressive effects on the expression of PPARα target genes, and these processes may be mediated by inhibiting the coactivator recruitment of PPARα. Thus, it is likely that PPARα functions on obesity may be enhanced in estrogen-deficient states.
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spelling pubmed-29431252010-09-24 PPARα in Obesity: Sex Difference and Estrogen Involvement Yoon, Michung PPAR Res Review Article Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for lipid and lipoprotein metabolism. PPARα activators are further shown to reduce body weight gain and adiposity, at least in part, due to the increase of hepatic fatty acid oxidation and the decrease in levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of the PPARα ligand fenofibrate on obesity are regulated with sexual dimorphism and seem to be influenced by the presence of functioning ovaries, suggesting the involvement of ovarian steroids in the control of obesity by PPARα. In female ovariectomized mice, 17β-estradiol inhibits the actions of fenofibrate on obesity through its suppressive effects on the expression of PPARα target genes, and these processes may be mediated by inhibiting the coactivator recruitment of PPARα. Thus, it is likely that PPARα functions on obesity may be enhanced in estrogen-deficient states. Hindawi Publishing Corporation 2010 2010-08-17 /pmc/articles/PMC2943125/ /pubmed/20871824 http://dx.doi.org/10.1155/2010/584296 Text en Copyright © 2010 Michung Yoon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yoon, Michung
PPARα in Obesity: Sex Difference and Estrogen Involvement
title PPARα in Obesity: Sex Difference and Estrogen Involvement
title_full PPARα in Obesity: Sex Difference and Estrogen Involvement
title_fullStr PPARα in Obesity: Sex Difference and Estrogen Involvement
title_full_unstemmed PPARα in Obesity: Sex Difference and Estrogen Involvement
title_short PPARα in Obesity: Sex Difference and Estrogen Involvement
title_sort pparα in obesity: sex difference and estrogen involvement
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943125/
https://www.ncbi.nlm.nih.gov/pubmed/20871824
http://dx.doi.org/10.1155/2010/584296
work_keys_str_mv AT yoonmichung pparainobesitysexdifferenceandestrogeninvolvement