PPARα in Obesity: Sex Difference and Estrogen Involvement
Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for li...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943125/ https://www.ncbi.nlm.nih.gov/pubmed/20871824 http://dx.doi.org/10.1155/2010/584296 |
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author | Yoon, Michung |
author_facet | Yoon, Michung |
author_sort | Yoon, Michung |
collection | PubMed |
description | Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for lipid and lipoprotein metabolism. PPARα activators are further shown to reduce body weight gain and adiposity, at least in part, due to the increase of hepatic fatty acid oxidation and the decrease in levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of the PPARα ligand fenofibrate on obesity are regulated with sexual dimorphism and seem to be influenced by the presence of functioning ovaries, suggesting the involvement of ovarian steroids in the control of obesity by PPARα. In female ovariectomized mice, 17β-estradiol inhibits the actions of fenofibrate on obesity through its suppressive effects on the expression of PPARα target genes, and these processes may be mediated by inhibiting the coactivator recruitment of PPARα. Thus, it is likely that PPARα functions on obesity may be enhanced in estrogen-deficient states. |
format | Text |
id | pubmed-2943125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29431252010-09-24 PPARα in Obesity: Sex Difference and Estrogen Involvement Yoon, Michung PPAR Res Review Article Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid hormone receptor superfamily and is well known to act as the molecular target for lipid-lowering drugs of the fibrate family. At the molecular level, PPARα regulates the transcription of a number of genes critical for lipid and lipoprotein metabolism. PPARα activators are further shown to reduce body weight gain and adiposity, at least in part, due to the increase of hepatic fatty acid oxidation and the decrease in levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of the PPARα ligand fenofibrate on obesity are regulated with sexual dimorphism and seem to be influenced by the presence of functioning ovaries, suggesting the involvement of ovarian steroids in the control of obesity by PPARα. In female ovariectomized mice, 17β-estradiol inhibits the actions of fenofibrate on obesity through its suppressive effects on the expression of PPARα target genes, and these processes may be mediated by inhibiting the coactivator recruitment of PPARα. Thus, it is likely that PPARα functions on obesity may be enhanced in estrogen-deficient states. Hindawi Publishing Corporation 2010 2010-08-17 /pmc/articles/PMC2943125/ /pubmed/20871824 http://dx.doi.org/10.1155/2010/584296 Text en Copyright © 2010 Michung Yoon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yoon, Michung PPARα in Obesity: Sex Difference and Estrogen Involvement |
title | PPARα in Obesity: Sex Difference and Estrogen Involvement |
title_full | PPARα in Obesity: Sex Difference and Estrogen Involvement |
title_fullStr | PPARα in Obesity: Sex Difference and Estrogen Involvement |
title_full_unstemmed | PPARα in Obesity: Sex Difference and Estrogen Involvement |
title_short | PPARα in Obesity: Sex Difference and Estrogen Involvement |
title_sort | pparα in obesity: sex difference and estrogen involvement |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943125/ https://www.ncbi.nlm.nih.gov/pubmed/20871824 http://dx.doi.org/10.1155/2010/584296 |
work_keys_str_mv | AT yoonmichung pparainobesitysexdifferenceandestrogeninvolvement |