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Peanut sensitization in a group of allergic Egyptian children

BACKGROUND: There are no published data on peanut sensitization in Egypt and the problem of peanut allergy seems underestimated. We sought to screen for peanut sensitization in a group of atopic Egyptian children in relation to their phenotypic manifestations. METHODS: We consecutively enrolled 100...

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Autores principales: Hossny, Elham, Gad, Ghada, Shehab, Abeer, El-Haddad, Amgad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126748/
https://www.ncbi.nlm.nih.gov/pubmed/21627816
http://dx.doi.org/10.1186/1710-1492-7-11
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author Hossny, Elham
Gad, Ghada
Shehab, Abeer
El-Haddad, Amgad
author_facet Hossny, Elham
Gad, Ghada
Shehab, Abeer
El-Haddad, Amgad
author_sort Hossny, Elham
collection PubMed
description BACKGROUND: There are no published data on peanut sensitization in Egypt and the problem of peanut allergy seems underestimated. We sought to screen for peanut sensitization in a group of atopic Egyptian children in relation to their phenotypic manifestations. METHODS: We consecutively enrolled 100 allergic children; 2-10 years old (mean 6.5 yr). The study measurements included clinical evaluation for site of allergy, possible precipitating factors, consumption of peanuts (starting age and last consumption), duration of breast feeding, current treatment, and family history of allergy as well as skin prick testing with a commercial peanut extract, and serum peanut specific and total IgE estimation. Children who were found sensitized to peanuts were subjected to an open oral peanut challenge test taking all necessary precautions. RESULTS: Seven subjects (7%) were sensitized and three out of six of them had positive oral challenge denoting allergy to peanuts. The sensitization rates did not vary significantly with gender, age, family history of allergy, breast feeding duration, clinical form of allergy, serum total IgE, or absolute eosinophil count. All peanut sensitive subjects had skin with or without respiratory allergy. CONCLUSIONS: Peanut allergy does not seem to be rare in atopic children in Egypt. Skin prick and specific IgE testing are effective screening tools to determine candidates for peanut oral challenging. Wider scale multicenter population-based studies are needed to assess the prevalence of peanut allergy and its clinical correlates in our country.
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spelling pubmed-31267482011-06-30 Peanut sensitization in a group of allergic Egyptian children Hossny, Elham Gad, Ghada Shehab, Abeer El-Haddad, Amgad Allergy Asthma Clin Immunol Research BACKGROUND: There are no published data on peanut sensitization in Egypt and the problem of peanut allergy seems underestimated. We sought to screen for peanut sensitization in a group of atopic Egyptian children in relation to their phenotypic manifestations. METHODS: We consecutively enrolled 100 allergic children; 2-10 years old (mean 6.5 yr). The study measurements included clinical evaluation for site of allergy, possible precipitating factors, consumption of peanuts (starting age and last consumption), duration of breast feeding, current treatment, and family history of allergy as well as skin prick testing with a commercial peanut extract, and serum peanut specific and total IgE estimation. Children who were found sensitized to peanuts were subjected to an open oral peanut challenge test taking all necessary precautions. RESULTS: Seven subjects (7%) were sensitized and three out of six of them had positive oral challenge denoting allergy to peanuts. The sensitization rates did not vary significantly with gender, age, family history of allergy, breast feeding duration, clinical form of allergy, serum total IgE, or absolute eosinophil count. All peanut sensitive subjects had skin with or without respiratory allergy. CONCLUSIONS: Peanut allergy does not seem to be rare in atopic children in Egypt. Skin prick and specific IgE testing are effective screening tools to determine candidates for peanut oral challenging. Wider scale multicenter population-based studies are needed to assess the prevalence of peanut allergy and its clinical correlates in our country. BioMed Central 2011-05-31 /pmc/articles/PMC3126748/ /pubmed/21627816 http://dx.doi.org/10.1186/1710-1492-7-11 Text en Copyright ©2011 Hossny et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hossny, Elham
Gad, Ghada
Shehab, Abeer
El-Haddad, Amgad
Peanut sensitization in a group of allergic Egyptian children
title Peanut sensitization in a group of allergic Egyptian children
title_full Peanut sensitization in a group of allergic Egyptian children
title_fullStr Peanut sensitization in a group of allergic Egyptian children
title_full_unstemmed Peanut sensitization in a group of allergic Egyptian children
title_short Peanut sensitization in a group of allergic Egyptian children
title_sort peanut sensitization in a group of allergic egyptian children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126748/
https://www.ncbi.nlm.nih.gov/pubmed/21627816
http://dx.doi.org/10.1186/1710-1492-7-11
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