Expression of Arf Tumor Suppressor in Spermatogonia Facilitates Meiotic Progression in Male Germ Cells

The mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins (p16(Ink4a) and p19(Arf)) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53 transcription factor in response to oncogenic stress. Although p19(Arf) is not normally det...

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Detalles Bibliográficos
Autores principales: Churchman, Michelle L., Roig, Ignasi, Jasin, Maria, Keeney, Scott, Sherr, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141002/
https://www.ncbi.nlm.nih.gov/pubmed/21811412
http://dx.doi.org/10.1371/journal.pgen.1002157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141002/
https://www.ncbi.nlm.nih.gov/pubmed/21811412
http://dx.doi.org/10.1371/journal.pgen.1002157

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