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Statistical Mutation Calling from Sequenced Overlapping DNA Pools in TILLING Experiments

BACKGROUND: TILLING (Targeting induced local lesions IN genomes) is an efficient reverse genetics approach for detecting induced mutations in pools of individuals. Combined with the high-throughput of next-generation sequencing technologies, and the resolving power of overlapping pool design, TILLIN...

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Detalles Bibliográficos
Autores principales: Missirian, Victor, Comai, Luca, Filkov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150297/
https://www.ncbi.nlm.nih.gov/pubmed/21756356
http://dx.doi.org/10.1186/1471-2105-12-287