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Visual assessment of posterior atrophy development of a MRI rating scale

OBJECTIVE: To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer’s disease (AD) and other dementias. METHODS: Magnetic resonance imaging of 118 memory clinic patients were analysed for PA (range 0–3), med...

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Autores principales: Koedam, Esther L. G. E., Lehmann, Manja, van der Flier, Wiesje M., Scheltens, Philip, Pijnenburg, Yolande A. L., Fox, Nick, Barkhof, Frederik, Wattjes, Mike P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217148/
https://www.ncbi.nlm.nih.gov/pubmed/21805370
http://dx.doi.org/10.1007/s00330-011-2205-4
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author Koedam, Esther L. G. E.
Lehmann, Manja
van der Flier, Wiesje M.
Scheltens, Philip
Pijnenburg, Yolande A. L.
Fox, Nick
Barkhof, Frederik
Wattjes, Mike P.
author_facet Koedam, Esther L. G. E.
Lehmann, Manja
van der Flier, Wiesje M.
Scheltens, Philip
Pijnenburg, Yolande A. L.
Fox, Nick
Barkhof, Frederik
Wattjes, Mike P.
author_sort Koedam, Esther L. G. E.
collection PubMed
description OBJECTIVE: To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer’s disease (AD) and other dementias. METHODS: Magnetic resonance imaging of 118 memory clinic patients were analysed for PA (range 0–3), medial temporal lobe atrophy (MTA) (range 0–4) and global cortical atrophy (range 0–3) by different raters. Weighted-kappas were calculated for inter- and intra-rater agreement. Relationships between PA and MTA with the MMSE and age were estimated with linear-regression analysis. RESULTS: Intra-rater agreement ranged between 0.93 and 0.95 and inter-rater agreement between 0.65 and 0.84. Mean PA scores were higher in AD compared to controls (1.6 ± 0.9 and 0.6 ± 0.7, p < 0.01), and other dementias (0.8 ± 0.8, p < 0.01). PA was not associated with age compared to MTA (B = 1.1 (0.8) versus B = 3.1 (0.7), p < 0.01)). PA and MTA were independently negatively associated with the MMSE (B = −1.6 (0.5), p < 0.01 versus B = −1.4 (0.5), p < 0.01). CONCLUSION: This robust and reproducible scale for PA assessment conveys independent information in a clinical setting and may be useful in the discrimination of AD from other dementias.
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spelling pubmed-32171482011-12-09 Visual assessment of posterior atrophy development of a MRI rating scale Koedam, Esther L. G. E. Lehmann, Manja van der Flier, Wiesje M. Scheltens, Philip Pijnenburg, Yolande A. L. Fox, Nick Barkhof, Frederik Wattjes, Mike P. Eur Radiol Neuro OBJECTIVE: To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer’s disease (AD) and other dementias. METHODS: Magnetic resonance imaging of 118 memory clinic patients were analysed for PA (range 0–3), medial temporal lobe atrophy (MTA) (range 0–4) and global cortical atrophy (range 0–3) by different raters. Weighted-kappas were calculated for inter- and intra-rater agreement. Relationships between PA and MTA with the MMSE and age were estimated with linear-regression analysis. RESULTS: Intra-rater agreement ranged between 0.93 and 0.95 and inter-rater agreement between 0.65 and 0.84. Mean PA scores were higher in AD compared to controls (1.6 ± 0.9 and 0.6 ± 0.7, p < 0.01), and other dementias (0.8 ± 0.8, p < 0.01). PA was not associated with age compared to MTA (B = 1.1 (0.8) versus B = 3.1 (0.7), p < 0.01)). PA and MTA were independently negatively associated with the MMSE (B = −1.6 (0.5), p < 0.01 versus B = −1.4 (0.5), p < 0.01). CONCLUSION: This robust and reproducible scale for PA assessment conveys independent information in a clinical setting and may be useful in the discrimination of AD from other dementias. Springer-Verlag 2011-07-31 2011 /pmc/articles/PMC3217148/ /pubmed/21805370 http://dx.doi.org/10.1007/s00330-011-2205-4 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Neuro
Koedam, Esther L. G. E.
Lehmann, Manja
van der Flier, Wiesje M.
Scheltens, Philip
Pijnenburg, Yolande A. L.
Fox, Nick
Barkhof, Frederik
Wattjes, Mike P.
Visual assessment of posterior atrophy development of a MRI rating scale
title Visual assessment of posterior atrophy development of a MRI rating scale
title_full Visual assessment of posterior atrophy development of a MRI rating scale
title_fullStr Visual assessment of posterior atrophy development of a MRI rating scale
title_full_unstemmed Visual assessment of posterior atrophy development of a MRI rating scale
title_short Visual assessment of posterior atrophy development of a MRI rating scale
title_sort visual assessment of posterior atrophy development of a mri rating scale
topic Neuro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217148/
https://www.ncbi.nlm.nih.gov/pubmed/21805370
http://dx.doi.org/10.1007/s00330-011-2205-4
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