Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes

Cigarette smoke (CS) causes sustained lung inflammation, which is an important event in the pathogenesis of chronic obstructive pulmonary disease (COPD). We have previously reported that IKKα (I kappaB kinase alpha) plays a key role in CS-induced pro-inflammatory gene transcription by chromatin modi...

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Detalles Bibliográficos
Autores principales: Sundar, Isaac K., Chung, Sangwoon, Hwang, Jae-woong, Lapek, John D., Bulger, Michael, Friedman, Alan E., Yao, Hongwei, Davie, James R., Rahman, Irfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270039/
https://www.ncbi.nlm.nih.gov/pubmed/22312446
http://dx.doi.org/10.1371/journal.pone.0031378