One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

The HIV-1, HIV-2 and SIV Nef protein are known to modulate the expression of several cell surface receptors and molecules to escape the immune system, to alter T cell activation, to enhance viral replication, infectivity and transmission and overall to ensure the optimal environment for infection ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Landi, Alessia, Iannucci, Veronica, Nuffel, Anouk Van, Meuwissen, Pieter, Verhasselt, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290772/
https://www.ncbi.nlm.nih.gov/pubmed/22103833
http://dx.doi.org/10.2174/157016211798842116
_version_ 1782225042723045376
author Landi, Alessia
Iannucci, Veronica
Nuffel, Anouk Van
Meuwissen, Pieter
Verhasselt, Bruno
author_facet Landi, Alessia
Iannucci, Veronica
Nuffel, Anouk Van
Meuwissen, Pieter
Verhasselt, Bruno
author_sort Landi, Alessia
collection PubMed
description The HIV-1, HIV-2 and SIV Nef protein are known to modulate the expression of several cell surface receptors and molecules to escape the immune system, to alter T cell activation, to enhance viral replication, infectivity and transmission and overall to ensure the optimal environment for infection outcome. Consistent and continuous efforts have been made over the years to characterize the modulation of expression of each of these molecules, in the hope that a better understanding of these processes essential for HIV infection and/or pathogenesis will eventually highlight new therapeutic targets. In this article we provide an extensive review of the knowledge gained so far on this important and evolving topic.
format Online
Article
Text
id pubmed-3290772
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Bentham Science Publishers
record_format MEDLINE/PubMed
spelling pubmed-32907722012-03-15 One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef Landi, Alessia Iannucci, Veronica Nuffel, Anouk Van Meuwissen, Pieter Verhasselt, Bruno Curr HIV Res Article The HIV-1, HIV-2 and SIV Nef protein are known to modulate the expression of several cell surface receptors and molecules to escape the immune system, to alter T cell activation, to enhance viral replication, infectivity and transmission and overall to ensure the optimal environment for infection outcome. Consistent and continuous efforts have been made over the years to characterize the modulation of expression of each of these molecules, in the hope that a better understanding of these processes essential for HIV infection and/or pathogenesis will eventually highlight new therapeutic targets. In this article we provide an extensive review of the knowledge gained so far on this important and evolving topic. Bentham Science Publishers 2011-10 2011-10 /pmc/articles/PMC3290772/ /pubmed/22103833 http://dx.doi.org/10.2174/157016211798842116 Text en © 2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Landi, Alessia
Iannucci, Veronica
Nuffel, Anouk Van
Meuwissen, Pieter
Verhasselt, Bruno
One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title_full One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title_fullStr One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title_full_unstemmed One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title_short One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef
title_sort one protein to rule them all: modulation of cell surface receptors and molecules by hiv nef
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290772/
https://www.ncbi.nlm.nih.gov/pubmed/22103833
http://dx.doi.org/10.2174/157016211798842116
work_keys_str_mv AT landialessia oneproteintorulethemallmodulationofcellsurfacereceptorsandmoleculesbyhivnef
AT iannucciveronica oneproteintorulethemallmodulationofcellsurfacereceptorsandmoleculesbyhivnef
AT nuffelanoukvan oneproteintorulethemallmodulationofcellsurfacereceptorsandmoleculesbyhivnef
AT meuwissenpieter oneproteintorulethemallmodulationofcellsurfacereceptorsandmoleculesbyhivnef
AT verhasseltbruno oneproteintorulethemallmodulationofcellsurfacereceptorsandmoleculesbyhivnef