Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as cancer, their global effects on the proteome remain largely unknown. Here we use high resolution, quantitative mass spectrometry to map protein expression changes associated w...

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Detalles Bibliográficos
Autores principales: Sharma, Kirti, Vabulas, R. Martin, Macek, Boris, Pinkert, Stefan, Cox, Jürgen, Mann, Matthias, Hartl, F. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Special Issue: Prospects in Space and Time
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316734/
https://www.ncbi.nlm.nih.gov/pubmed/22167270
http://dx.doi.org/10.1074/mcp.M111.014654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316734/
https://www.ncbi.nlm.nih.gov/pubmed/22167270
http://dx.doi.org/10.1074/mcp.M111.014654

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