Mannose 6-Phosphate Receptor and Sortilin Mediated Endocytosis of α-Galactosidase A in Kidney Endothelial Cells

Prominent vasculopathy in Fabry disease patients is caused by excessive intracellular accumulation of globotriaosylceramide (GL-3) throughout the vascular endothelial cells causing progressive cerebrovascular, cardiac and renal impairments. The vascular lesions lead to myocardial ischemia, atherogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Prabakaran, Thaneas, Nielsen, Rikke, Satchell, Simon C., Mathieson, Peter W., Feldt-Rasmussen, Ulla, Sørensen, Søren S., Christensen, Erik I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386966/
https://www.ncbi.nlm.nih.gov/pubmed/22768187
http://dx.doi.org/10.1371/journal.pone.0039975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386966/
https://www.ncbi.nlm.nih.gov/pubmed/22768187
http://dx.doi.org/10.1371/journal.pone.0039975

Ejemplares similares