Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study

BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (...

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Autores principales: Kallel, Choumous, Cohen, William, Saut, Noémie, Blankenberg, Stefan, Schnabel, Renate, Rupprecht, Hans J, Bickel, Christoph, Munzel, Thomas, Tregouet, David-Alexandre, Morange, Pierre-Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523004/
https://www.ncbi.nlm.nih.gov/pubmed/23136988
http://dx.doi.org/10.1186/1471-2350-13-103
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author Kallel, Choumous
Cohen, William
Saut, Noémie
Blankenberg, Stefan
Schnabel, Renate
Rupprecht, Hans J
Bickel, Christoph
Munzel, Thomas
Tregouet, David-Alexandre
Morange, Pierre-Emmanuel
author_facet Kallel, Choumous
Cohen, William
Saut, Noémie
Blankenberg, Stefan
Schnabel, Renate
Rupprecht, Hans J
Bickel, Christoph
Munzel, Thomas
Tregouet, David-Alexandre
Morange, Pierre-Emmanuel
author_sort Kallel, Choumous
collection PubMed
description BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE). METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant. RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10(-200)) but did not associate with CVE risk. CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
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spelling pubmed-35230042012-12-16 Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study Kallel, Choumous Cohen, William Saut, Noémie Blankenberg, Stefan Schnabel, Renate Rupprecht, Hans J Bickel, Christoph Munzel, Thomas Tregouet, David-Alexandre Morange, Pierre-Emmanuel BMC Med Genet Research Article BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE). METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant. RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10(-200)) but did not associate with CVE risk. CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE. BioMed Central 2012-11-08 /pmc/articles/PMC3523004/ /pubmed/23136988 http://dx.doi.org/10.1186/1471-2350-13-103 Text en Copyright ©2012 Kallel et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kallel, Choumous
Cohen, William
Saut, Noémie
Blankenberg, Stefan
Schnabel, Renate
Rupprecht, Hans J
Bickel, Christoph
Munzel, Thomas
Tregouet, David-Alexandre
Morange, Pierre-Emmanuel
Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title_full Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title_fullStr Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title_full_unstemmed Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title_short Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The Athero Gene Study
title_sort association of soluble endothelial protein c receptor plasma levels and procr rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the athero gene study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523004/
https://www.ncbi.nlm.nih.gov/pubmed/23136988
http://dx.doi.org/10.1186/1471-2350-13-103
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