Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors

Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostaglandins, which are mediators of inflammation. It exists mainly in two isoforms COX-1 and COX-2. The conventional nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects becaus...

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Detalles Bibliográficos
Autores principales: Vernieri, Ermelinda, Gomez-Monterrey, Isabel, Milite, Ciro, Grieco, Paolo, Musella, Simona, Bertamino, Alessia, Scognamiglio, Ilaria, Alcaro, Stefano, Artese, Anna, Ortuso, Francesco, Novellino, Ettore, Sala, Marina, Campiglia, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600326/
https://www.ncbi.nlm.nih.gov/pubmed/23533709
http://dx.doi.org/10.1155/2013/606282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600326/
https://www.ncbi.nlm.nih.gov/pubmed/23533709
http://dx.doi.org/10.1155/2013/606282

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