Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer

BACKGROUND: Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in...

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Autores principales: Snoeren, N, Emmink, B L, Koerkamp, M J G, van Hooff, S R, Goos, J A C M, van Houdt, W J, de Wit, M, Prins, A M, Piersma, S R, Pham, T V, Belt, E J, Bril, H, Stockmann, H B, Meijer, G A, van Hillegersberg, R, Holstege, F C, Jimenez, C R, Fijneman, R J A, Kranenburg, O W, Rinkes, I H M Borel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776998/
https://www.ncbi.nlm.nih.gov/pubmed/24002600
http://dx.doi.org/10.1038/bjc.2013.489
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author Snoeren, N
Emmink, B L
Koerkamp, M J G
van Hooff, S R
Goos, J A C M
van Houdt, W J
de Wit, M
Prins, A M
Piersma, S R
Pham, T V
Belt, E J
Bril, H
Stockmann, H B
Meijer, G A
van Hillegersberg, R
Holstege, F C
Jimenez, C R
Fijneman, R J A
Kranenburg, O W
Rinkes, I H M Borel
author_facet Snoeren, N
Emmink, B L
Koerkamp, M J G
van Hooff, S R
Goos, J A C M
van Houdt, W J
de Wit, M
Prins, A M
Piersma, S R
Pham, T V
Belt, E J
Bril, H
Stockmann, H B
Meijer, G A
van Hillegersberg, R
Holstege, F C
Jimenez, C R
Fijneman, R J A
Kranenburg, O W
Rinkes, I H M Borel
author_sort Snoeren, N
collection PubMed
description BACKGROUND: Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CRC. METHODS: Gene expression profiling and proteomics were used to identify differentially expressed genes/proteins in resected liver metastases that recurred within 6 months following liver surgery vs those that did not recur for >24 months. Expression of the identified genes/proteins in stage II (n=243) and III (n=176) tumours was analysed by immunohistochemistry on tissue microarrays. Correlation of protein levels with stage-specific outcome was assessed by uni- and multivariable analyses. RESULTS: Both gene expression profiling and proteomics identified Maspin to be differentially expressed in colorectal liver metastases with early (<6 months) and prolonged (>24 months) time to recurrence. Immunohistochemical analysis of Maspin expression on tumour sections revealed that it was an independent predictor of time to recurrence (log-rank P=0.004) and CRC-specific survival (P=0.000) in stage III CRC. High Maspin expression was also correlated with mucinous differentiation. In stage II CRC patients, high Maspin expression did not correlate with survival but was correlated with a right-sided tumour location. CONCLUSION: High Maspin expression correlates with poor outcome in CRC after spread to the local lymph nodes. Therefore, Maspin may have a stage-specific function possibly related to tumour cell dissemination and/or metastatic outgrowth.
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spelling pubmed-37769982014-09-17 Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer Snoeren, N Emmink, B L Koerkamp, M J G van Hooff, S R Goos, J A C M van Houdt, W J de Wit, M Prins, A M Piersma, S R Pham, T V Belt, E J Bril, H Stockmann, H B Meijer, G A van Hillegersberg, R Holstege, F C Jimenez, C R Fijneman, R J A Kranenburg, O W Rinkes, I H M Borel Br J Cancer Molecular Diagnostics BACKGROUND: Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CRC. METHODS: Gene expression profiling and proteomics were used to identify differentially expressed genes/proteins in resected liver metastases that recurred within 6 months following liver surgery vs those that did not recur for >24 months. Expression of the identified genes/proteins in stage II (n=243) and III (n=176) tumours was analysed by immunohistochemistry on tissue microarrays. Correlation of protein levels with stage-specific outcome was assessed by uni- and multivariable analyses. RESULTS: Both gene expression profiling and proteomics identified Maspin to be differentially expressed in colorectal liver metastases with early (<6 months) and prolonged (>24 months) time to recurrence. Immunohistochemical analysis of Maspin expression on tumour sections revealed that it was an independent predictor of time to recurrence (log-rank P=0.004) and CRC-specific survival (P=0.000) in stage III CRC. High Maspin expression was also correlated with mucinous differentiation. In stage II CRC patients, high Maspin expression did not correlate with survival but was correlated with a right-sided tumour location. CONCLUSION: High Maspin expression correlates with poor outcome in CRC after spread to the local lymph nodes. Therefore, Maspin may have a stage-specific function possibly related to tumour cell dissemination and/or metastatic outgrowth. Nature Publishing Group 2013-09-17 2013-09-03 /pmc/articles/PMC3776998/ /pubmed/24002600 http://dx.doi.org/10.1038/bjc.2013.489 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Molecular Diagnostics
Snoeren, N
Emmink, B L
Koerkamp, M J G
van Hooff, S R
Goos, J A C M
van Houdt, W J
de Wit, M
Prins, A M
Piersma, S R
Pham, T V
Belt, E J
Bril, H
Stockmann, H B
Meijer, G A
van Hillegersberg, R
Holstege, F C
Jimenez, C R
Fijneman, R J A
Kranenburg, O W
Rinkes, I H M Borel
Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title_full Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title_fullStr Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title_full_unstemmed Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title_short Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer
title_sort maspin is a marker for early recurrence in primary stage iii and iv colorectal cancer
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776998/
https://www.ncbi.nlm.nih.gov/pubmed/24002600
http://dx.doi.org/10.1038/bjc.2013.489
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