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Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies have shown that resveratrol supplementation reduces blood glucose levels, preserves β-cells in islets of Langerhans, and i...

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Autores principales: Fiori, Jennifer L., Shin, Yu-Kyong, Kim, Wook, Krzysik-Walker, Susan M., González-Mariscal, Isabel, Carlson, Olga D., Sanghvi, Mitesh, Moaddel, Ruin, Farhang, Kathleen, Gadkaree, Shekhar K., Doyle, Maire E., Pearson, Kevin J., Mattison, Julie A., de Cabo, Rafael, Egan, Josephine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781448/
https://www.ncbi.nlm.nih.gov/pubmed/23884882
http://dx.doi.org/10.2337/db13-0266
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author Fiori, Jennifer L.
Shin, Yu-Kyong
Kim, Wook
Krzysik-Walker, Susan M.
González-Mariscal, Isabel
Carlson, Olga D.
Sanghvi, Mitesh
Moaddel, Ruin
Farhang, Kathleen
Gadkaree, Shekhar K.
Doyle, Maire E.
Pearson, Kevin J.
Mattison, Julie A.
de Cabo, Rafael
Egan, Josephine M.
author_facet Fiori, Jennifer L.
Shin, Yu-Kyong
Kim, Wook
Krzysik-Walker, Susan M.
González-Mariscal, Isabel
Carlson, Olga D.
Sanghvi, Mitesh
Moaddel, Ruin
Farhang, Kathleen
Gadkaree, Shekhar K.
Doyle, Maire E.
Pearson, Kevin J.
Mattison, Julie A.
de Cabo, Rafael
Egan, Josephine M.
author_sort Fiori, Jennifer L.
collection PubMed
description Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies have shown that resveratrol supplementation reduces blood glucose levels, preserves β-cells in islets of Langerhans, and improves insulin action. Although rodent models are helpful for understanding β-cell biology and certain aspects of T2DM pathology, they fail to reproduce the complexity of the human disease as well as that of nonhuman primates. Rhesus monkeys were fed a standard diet (SD), or a high-fat/high-sugar diet in combination with either placebo (HFS) or resveratrol (HFS+Resv) for 24 months, and pancreata were examined before overt dysglycemia occurred. Increased glucose-stimulated insulin secretion and insulin resistance occurred in both HFS and HFS+Resv diets compared with SD. Although islet size was unaffected, there was a significant decrease in β-cells and an increase in α-cells containing glucagon and glucagon-like peptide 1 with HFS diets. Islets from HFS+Resv monkeys were morphologically similar to SD. HFS diets also resulted in decreased expression of essential β-cell transcription factors forkhead box O1 (FOXO1), NKX6–1, NKX2–2, and PDX1, which did not occur with resveratrol supplementation. Similar changes were observed in human islets where the effects of resveratrol were mediated through Sirtuin 1. These findings have implications for the management of humans with insulin resistance, prediabetes, and diabetes.
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spelling pubmed-37814482014-10-01 Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet Fiori, Jennifer L. Shin, Yu-Kyong Kim, Wook Krzysik-Walker, Susan M. González-Mariscal, Isabel Carlson, Olga D. Sanghvi, Mitesh Moaddel, Ruin Farhang, Kathleen Gadkaree, Shekhar K. Doyle, Maire E. Pearson, Kevin J. Mattison, Julie A. de Cabo, Rafael Egan, Josephine M. Diabetes Original Research Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies have shown that resveratrol supplementation reduces blood glucose levels, preserves β-cells in islets of Langerhans, and improves insulin action. Although rodent models are helpful for understanding β-cell biology and certain aspects of T2DM pathology, they fail to reproduce the complexity of the human disease as well as that of nonhuman primates. Rhesus monkeys were fed a standard diet (SD), or a high-fat/high-sugar diet in combination with either placebo (HFS) or resveratrol (HFS+Resv) for 24 months, and pancreata were examined before overt dysglycemia occurred. Increased glucose-stimulated insulin secretion and insulin resistance occurred in both HFS and HFS+Resv diets compared with SD. Although islet size was unaffected, there was a significant decrease in β-cells and an increase in α-cells containing glucagon and glucagon-like peptide 1 with HFS diets. Islets from HFS+Resv monkeys were morphologically similar to SD. HFS diets also resulted in decreased expression of essential β-cell transcription factors forkhead box O1 (FOXO1), NKX6–1, NKX2–2, and PDX1, which did not occur with resveratrol supplementation. Similar changes were observed in human islets where the effects of resveratrol were mediated through Sirtuin 1. These findings have implications for the management of humans with insulin resistance, prediabetes, and diabetes. American Diabetes Association 2013-10 2013-09-17 /pmc/articles/PMC3781448/ /pubmed/23884882 http://dx.doi.org/10.2337/db13-0266 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Fiori, Jennifer L.
Shin, Yu-Kyong
Kim, Wook
Krzysik-Walker, Susan M.
González-Mariscal, Isabel
Carlson, Olga D.
Sanghvi, Mitesh
Moaddel, Ruin
Farhang, Kathleen
Gadkaree, Shekhar K.
Doyle, Maire E.
Pearson, Kevin J.
Mattison, Julie A.
de Cabo, Rafael
Egan, Josephine M.
Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title_full Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title_fullStr Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title_full_unstemmed Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title_short Resveratrol Prevents β-Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet
title_sort resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781448/
https://www.ncbi.nlm.nih.gov/pubmed/23884882
http://dx.doi.org/10.2337/db13-0266
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