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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Recognition of injured mitochondria for degradation by macroautophagy is essential for cellular health, but the mechanisms remain poorly understood. Cardiolipin is an inner mitochondrial membrane phospholipid. We found that rotenone, staurosporine, 6-hydroxydopamine and other pro-mitophagy stimuli c...

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Detalles Bibliográficos
Autores principales: Chu, Charleen T., Ji, Jing, Dagda, Ruben K., Jiang, Jian Fei, Tyurina, Yulia Y., Kapralov, Alexandr A., Tyurin, Vladimir A., Yanamala, Naveena, Shrivastava, Indira H., Mohammadyani, Dariush, Wang, Kent Zhi Qiang, Zhu, Jianhui, Klein-Seetharaman, Judith, Balasubramanian, Krishnakumar, Amoscato, Andrew A., Borisenko, Grigory, Huang, Zhentai, Gusdon, Aaron M., Cheikhi, Amin, Steer, Erin K., Wang, Ruth, Baty, Catherine, Watkins, Simon, Bahar, Ivet, Bayir, Hülya, Kagan, Valerian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806088/
https://www.ncbi.nlm.nih.gov/pubmed/24036476
http://dx.doi.org/10.1038/ncb2837