Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel

Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of commonly used chemotherapeutic agents. However, there are no effective strategies to treat the neuropathy. We examined whether Goshajinkigan, a herbal medicine, would prevent paclitaxel-induced allodynia without affec...

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Autores principales: Bahar, Muh. Akbar, Andoh, Tsugunobu, Ogura, Keisuke, Hayakawa, Yoshihiro, Saiki, Ikuo, Kuraishi, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807841/
https://www.ncbi.nlm.nih.gov/pubmed/24198846
http://dx.doi.org/10.1155/2013/849754
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author Bahar, Muh. Akbar
Andoh, Tsugunobu
Ogura, Keisuke
Hayakawa, Yoshihiro
Saiki, Ikuo
Kuraishi, Yasushi
author_facet Bahar, Muh. Akbar
Andoh, Tsugunobu
Ogura, Keisuke
Hayakawa, Yoshihiro
Saiki, Ikuo
Kuraishi, Yasushi
author_sort Bahar, Muh. Akbar
collection PubMed
description Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of commonly used chemotherapeutic agents. However, there are no effective strategies to treat the neuropathy. We examined whether Goshajinkigan, a herbal medicine, would prevent paclitaxel-induced allodynia without affecting the anticancer action in mice. Murine breast cancer 4T1 cells were inoculated into the mammary fat pad. Paclitaxel (10 and 20 mg/kg, intraperitoneal, alternate day from day 7 postinoculation) inhibited the tumor growth, and Goshajinkigan (1 g/kg, oral, daily from day 2 postinoculation) did not affect the antitumor action of paclitaxel. Mechanical allodynia developed in the inoculated region due to tumor growth and in the hind paw due to paclitaxel-induced neuropathy. Paclitaxel-induced allodynia was markedly prevented by Goshajinkigan, although tumor-associated allodynia was not inhibited by Goshajinkigan. These results suggest that Goshajinkigan prevents paclitaxel-induced peripheral neuropathy without interfering with the anti-cancer action of paclitaxel.
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spelling pubmed-38078412013-11-06 Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel Bahar, Muh. Akbar Andoh, Tsugunobu Ogura, Keisuke Hayakawa, Yoshihiro Saiki, Ikuo Kuraishi, Yasushi Evid Based Complement Alternat Med Research Article Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of commonly used chemotherapeutic agents. However, there are no effective strategies to treat the neuropathy. We examined whether Goshajinkigan, a herbal medicine, would prevent paclitaxel-induced allodynia without affecting the anticancer action in mice. Murine breast cancer 4T1 cells were inoculated into the mammary fat pad. Paclitaxel (10 and 20 mg/kg, intraperitoneal, alternate day from day 7 postinoculation) inhibited the tumor growth, and Goshajinkigan (1 g/kg, oral, daily from day 2 postinoculation) did not affect the antitumor action of paclitaxel. Mechanical allodynia developed in the inoculated region due to tumor growth and in the hind paw due to paclitaxel-induced neuropathy. Paclitaxel-induced allodynia was markedly prevented by Goshajinkigan, although tumor-associated allodynia was not inhibited by Goshajinkigan. These results suggest that Goshajinkigan prevents paclitaxel-induced peripheral neuropathy without interfering with the anti-cancer action of paclitaxel. Hindawi Publishing Corporation 2013 2013-10-02 /pmc/articles/PMC3807841/ /pubmed/24198846 http://dx.doi.org/10.1155/2013/849754 Text en Copyright © 2013 Muh. Akbar Bahar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bahar, Muh. Akbar
Andoh, Tsugunobu
Ogura, Keisuke
Hayakawa, Yoshihiro
Saiki, Ikuo
Kuraishi, Yasushi
Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title_full Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title_fullStr Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title_full_unstemmed Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title_short Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
title_sort herbal medicine goshajinkigan prevents paclitaxel-induced mechanical allodynia without impairing antitumor activity of paclitaxel
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807841/
https://www.ncbi.nlm.nih.gov/pubmed/24198846
http://dx.doi.org/10.1155/2013/849754
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