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Wound Healing Improvement with PHD-2 Silenced Fibroblasts in Diabetic Mice
BACKGROUND: Hypoxia-inducible factor 1α is the central regulator of the hypoxia-induced response which results in the up-regulation of angiogenic factors. Its activity is under precise regulation of prolyl-hydroxylase domain 2. We hypothesized that PHD2 silenced fibroblasts would increase the expres...
Autores principales: | Zhang, Xiongliang, Yan, Xiaoyu, Cheng, Liang, Dai, Jiezhi, Wang, Chunyang, Han, Pei, Chai, Yimin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869847/ https://www.ncbi.nlm.nih.gov/pubmed/24376825 http://dx.doi.org/10.1371/journal.pone.0084548 |
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