Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells

Down's syndrome (DS), a major genetic cause of mental retardation, arises from triplication of genes on human chromosome 21. Here we show that DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A) and DSCR1 (DS critical region 1), two genes lying within human chromosome 21...

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Detalles Bibliográficos
Autores principales: Kurabayashi, Nobuhiro, Sanada, Kamon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877759/
https://www.ncbi.nlm.nih.gov/pubmed/24352425
http://dx.doi.org/10.1101/gad.226381.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877759/
https://www.ncbi.nlm.nih.gov/pubmed/24352425
http://dx.doi.org/10.1101/gad.226381.113

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